Takako is a background character for most of the series, though she's often seen with Izumi Akazawa. She and Yumi Ogura are apparently her assistants as Head of Countermeasures, as the three are often together. She was present for Kōichi Sakakibara's first day of school ("Rough Sketch") but was not among the students who welcomed him to the class, instead remaining at her desk with Junta Nakao and Yumi, though she did occasionally stop to glare at him from time to time.
In "Put Flesh", she, Izumi, and Junta discussed Yukari Sakuragi's death, the curse, and Kōichi's role therein. Takako suggested everything was merely coincidental and tried to console Izumi when her friend tried to blame herself for Yukari's fate, telling her it couldn't be helped; she also advised against blaming Kōichi for their friend's demise, and suggested they instead focus on protecting the rest of the class. She was present for Mr. Kubodera's suicide, and like the other students, she sat and watched as Kubodera repeatedly stabbed himself with a knife. She was the only student not visibly disturbed by this event.
In "Hair Stand", Takako accompanied Kōichi and the others when they went to the beach to relax. Takako tried to assist Junta, who was apparently suffering from car sickness. Yūya Mochizuki gets buried in sand by Kōichi and Izumi while Takako tickles his feet as revenge for him and Naoya Teshigawara tossing her into the ocean earlier. She was paired with Naoya and Izumi for Naoya's fishing contest, though what, if anything, she caught is never shown. Later, while playing volleyball, a strong gust of wind caused her ball to fly into the water. Junta went after it, only to suddenly stop moving in the water. Naoya, Kōichi, and Katsumi Matsunaga rushed into the water to save him, the girls and Yūya watching from the shore. Unfortunately, they were too late, as a speeding yacht hit Junta before anyone could reach him and eviscerated his body. Upon seeing Junta's body flying out of the water, Takako dropped into a ball and screamed.
Takako was devastated by his death, and in "Body Paint", Izumi accompanied her home from Junta's funeral to ensure she was alright. Later on, Izumi confided that Takako had become increasingly unstable as a result.
Takako was one of the students who went on the school trip, sharing a room with Izumi at the inn.
In "Makeup", Takako revealed to Izumi that she was in elementary school with someone called "Misaki", who did not wear an eyepatch. Later on, a commotion in the main hall caused Izumi to leave Takako alone so she could go investigate. Upon encountering Mei Misaki and Kōichi, the trio heard Takako scream. Returning to the room, Izumi, Kōichi, and Mei check on her. The trio finds the girls' room covered in blood, and no sign of their friend. The group assumes the worst: someone had attacked Takako and killed her.
But Takako reappeared later, very much alive but covered in blood and carrying a knife, with one of her hands bandaged, her sanity apparently having deserted her. After expressing relief that Izumi was still alive, Takako comments that she would prefer not to live if the other girl died, before attacking Mei. Only Kōichi's intervention protected her. Takako fled to the inn's radio room and broadcast the tape Yūya found, telling everyone that Mei is the dead one and asking them to kill her. Izumi, hearing the broadcast and realizing Takako wasn't in her right mind, hurried to find her, leaving Kōichi to protect Mei.
Takako reappeared in the stairwell after the explosion, stabbing a distracted Kōichi in the arm to immobilize him, before explaining she didn't plan to kill him, because Izumi "seems fond" of him. Laughing hysterically, she then attacked Mei a second time, only to become entangled in a bundle of electrical cables and strangle herself, much to Kōichi and Mei's horror.
Izumi arrives immediately after and sees Mei and Kōichi standing underneath the dead body of her friend. Drawing the wrong conclusion and heartbroken by her friend's death, Izumi vowed to kill Mei in revenge.
In the film, Takako has a minor role, and she and Izumi have an odd relationship, as, among other things, Izumi never calls Takako by anything other than her last name, suggesting the two aren't especially close; their relationship tends to be much more abusive and unhealthy. While Izumi calms Takako down after she learns she's to be "the one who does not exist" for the year, the two aren't especially friendly. Izumi and Takako trail Kōichi to Mei's aunt's studio early on, and are horrified to learn where they are. The two sit together on the bus to the inn and share a room. At dinner that night, Takako attempts to sit with Mei and Kouichi, only for Izumi to irritably snap at her and tell her to sit somewhere else. Like Izumi, Takako confronts Mei and Kōichi at the inn, telling Kōichi she blames him for the calamity.
When Tomohiko Kazami tells the girls how to break the curse, Takako adamantly refuses to kill anyone, which angers Izumi. A short in the inn's electrical system traps them in the girls' room and makes Izumi suspicious of her roommate. Telling her she's always pretended to be "a good girl," Izumi informs Takako she thinks she's the Extra, prompting an angry response from Tomohiko. The two argue, but Izumi wins and stabs Takako in the throat. Shortly thereafter, Mei and Naoya arrive and find Izumi standing over the injured girl, who was desperately trying not to bleed to death. Almost immediately afterward, Naoya is killed, causing Izumi to realize that trying to kill Takako hasn't solved anything. Unconcerned, she attacked Mei next, leaving Tomohiko to help Takako escape.